chiefly in the interior of the continent.[clarification needed] But the tentacles of English maritime

During the Tudor period the Reformation produced a gradual shift to Protestantism, with much of London passing from church to private ownership.[56] The traffic in woollen cloths shipped undyed and undressed from London to the nearby shores of the Low Countries, for use by well-to-do wearers chiefly in the interior of the continent.[clarification needed] But the tentacles of English maritime enterprise hardly extended beyond the seas of north-west Europe. The commercial route to Italy and the Mediterranean Sea normally lay through Antwerp and over the Alps; any ships passing through the Strait of Gibraltar to or from England were likely to be Italian or Ragusan. Upon the re-opening of the Netherlands to English shipping in January 1565 there at once ensued a strong outburst of commercial activity.[57] The Royal Exchange was founded.[58] Mercantilism grew and monopoly trading companies such as the East India Company were established, with trade expanding to the New World. London became the principal North Sea port, with migrants arriving from England and abroad. The population rose from an estimated 50,000 in 1530 to about 225,000 in 1605.[56]
In the 16th century William Shakespeare and his contemporaries lived in London at a time of hostility to the development of the theatre. By the end of the Tudor period in 1603, London was still very compact. There was an assassination attempt on James I in Westminster, through the Gunpowder Plot on 5 November 1605.[59] London was plagued by disease in the early 17th century,[60] culminating in the Great Plague of 1665–1666, which killed up to 100,000 people, or a fifth of the population.[61]
The Great Fire of London broke out in 1666 in Pudding Lane in the city and quickly swept through the wooden buildings.[62] Rebuilding took over ten years and was supervised by Robert Hooke[63][64][65] as Surveyor of London.[66] In 1708 Christopher Wren's masterpiece, St Paul's Cathedral was completed. During the Georgian era new districts such as Mayfair were formed in the west; and new bridges over the Thames encouraged development in South London. In the east, the Port of London expanded downstream.
In 1762, George III acquired Buckingham House and it was enlarged over the next 75 years. During the 18th century, London was dogged by crime and the Bow Street Runners were established in 1750 as a professional police force.[67] In total, more than 200 offences were punishable by death,[68] and women and children were hanged for petty theft.[69] Over 74 per cent of children born in London died before they were five.[70] The coffeehouse became a popular place to debate ideas, with growing literacy and the development of the printing press making news widely available; and Fleet Street became the centre of the British press.
According to Samuel Johnson:
You find no man, at all intellectual, who is willing to leave London. No, Sir, when a man is tired of London, he is tired of life; for there is in London all that life can afford